Modeling of mean platelet volume
by
Arier Chi-Lun Lee
The University of Auckland, Auckland, New Zealand
Coauthors: Robert Gentleman (The University of Auckland, Auckland, New Zealand), Philip M. W. Bath (Division of Stroke Medicine, City Hospital, Nottingham, UK)

Platelets are discoid cells of the blood. Large platelets appear to be associated with increased platelet coagulability and increased risk of heart attack and stroke. Platelet size is often measured by mean platelet volume (MPV) which is now a standard measurement reported in blood analyses. However the reliability of MPV measurement is yet to be established.

Blood samples analysed at the time of venipuncture give more reliable MPV measurements then when blood analyses are delayed. Trowbridge et al [Clin. Phys. Physiol. Meas. 6 (1985):221-238] proposed a method for extrapolating MPV to the time of venipuncture using MPV measured at some other time point.

In this talk two models for extrapolating MPV to the time of venipuncture will be presented. For the first model, MPV was modeled as a function of the logarithmic transformed time until the blood analysis using a linear least square approach. Secondly MPV was modeled as a function of the untransformed time using a non-linear least squares approach. The results from those two models were compared with Trowbridge's method.

Date received: June 27, 2000

Copyright © 2000 by the author(s). The author(s) of this document and the organizers of the conference have granted their consent to include this abstract in Atlas Conferences Inc. Document # cadt-08.