Computation of probabilities associated with continuous genome data from full-sibs
by
Valeri T. Stefanov
The University of Western Australia

In this talk a technology will be discussed for numerical evaluation, with any given accuracy, of the cumulative probabilities of statistics on continuous genome data for a pair of full-sibs. The genomic continuum model, with Haldane's model for the crossover process, is assumed. The statistics of interest are: the proportion of genome with 2 haplotypes shared identical-by-descent (IBD) on a chromosomal segment, the proportion of genome with at least 1 haplotype shared IBD on a chromosomal segment, the number of distinct pieces (subsegments) of a chromosomal segment, on each of which exactly 2 haplotypes are shared IBD, the number of distinct pieces (subsegments) of a chromosomal segment, on each of which at least 1 haplotype is shared IBD.

Date received: August 30, 2001