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16th Australian Statistical Conference
July 7-11, 2002
National Convention Centre
Canberra, ACT, Australia

Organizers
Statistical Society of Australia Incorporated, Michael Adena - Chair Organising Committee, Kerrie Mengersen - Chair Program Committee

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Print-order normalization for cDNA microarrays
by
Gordon K Smyth
Walter and Eliza Hall Institute of Medical Research

Spotted DNA microarrays are a technology to measure the relative expression level for tens of thousands of genes simultaneously. Spotted microarray data depends on the relative intensity of red and green dyes for 10-40 thousand spots on a glass slide. One of the crucial early steps in the analysis of such data is to correct for red-green dye-bias. Current methods adjust dye-bias according to spatial position on the slide or according to spot intensity. In this talk I will discuss the desirability of adjusting also for time order corresponding to the order which the spots are printed on the slide.

Date received: April 1, 2002

Copyright © 2002 by the author(s). The author(s) of this document and the organizers of the conference have granted their consent to include this abstract in Atlas Conferences Inc. Document # caij-52.