Implantable controlled-release drug delivery systems - A computational design approach
by
Richard Collins
Pittsburgh, PA
Coauthors: N. Jinuntuya (Kasetsart University, Department of Physics, Bangkok 10900, Thailand), S. Wasuwanich (Kasetsart University, Department of Mathematics, Bangkok 10900, Thailand), P. Petpirom (Kasetsart University, Department of Mathematics, Bangkok 10900, Thailand)

Reliable predictive mathematical and computational models are formulated for implanted drug delivery systems in which therapeutic drugs have been incorporated into capsules and monolithic matrices. The time-release rate history is computed as a function of the particular characteristics of the matrix, its porosity, thickness, biodegradability and the properties of the drug embedded within its pores: molecular weight, concentration distribution, taking into account diffusion out of the implanted matrix, metabolic activity and uptake by the circulatory system. The specific features of these mathematical models are their ability to: (i) predict suitable dosages for other drugs of differing chemical and molecular properties which have not yet been subjected to time-consuming animal laboratory testing; and (ii) scale the doses of therapeutic drugs to other individual factors with applications to both clinical and veterinary medicine.

Date received: November 25, 2002