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First International Workshop in Sequential Methodologies (IWSM 2007)
July 22-25, 2007
Auburn University
Auburn, AL, U.S.A.

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Adaptive design to find the best diagnostic biomarker.
by
Chengqing(Alan) Wu
NICHD
Coauthors: Aiyi Liu, Kai F. YU

One objective in diagnostic study is to find the best biomarker among several competing biomarkers and then to show superiority of this biomarker to the standard one. For ethical and economical reasons, a adaptive two stage design will be proposed. At first stage we will estimate the best biomaker by areas under the receiver operating characteristic (ROC) curves(AUC), and stop the study if there is enough evidence for accepting or rejecting superiority. Otherwise, the second stage is carried out with the best biomarker estimate and the standard biomarker. Sample Size of second stage will be estimated based information from the first stage. The performance of the design will be investigated numerically.

Date received: April 15, 2007

Copyright © 2007 by the author(s). The author(s) of this document and the organizers of the conference have granted their consent to include this abstract in Atlas Conferences Inc. Document # cauc-70.