Blasting Neuroblastoma Using Optimal Control of Chemotherapy
by
Craig Collins and Molly Williams
Murray State University

The combination of mathematical modeling and optimal control theory provides a strong basis

for determining the most beneficial treatment methods for cancer patients. In particular,

the effectiveness of new drugs may be analyzed mathematically, generating important data for

clinical researchers. In this talk, we will discuss a model developed at St. Jude Children's

Research Hospital to investigate the usefulness of the drug Topotecan (TPT) as a treatment

for neuroblastoma, a type of cancer that typically targets young children. Optimal control

theory is applied to find the treatment schedule that minimizes both tumor volume and the

negative effects of chemotherapy.

Date received: September 18, 2007