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A Mathematical Model for the Effects of HER2 Over expression on Cell Cycle Progression in Breast Cancer
by
Amina Eladdadi
Department of Mathematical Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
Coauthors: David Isaacson
We present a mathematical model to study the effects of HER2 over-expression on cell-cycle progression in breast cancer. The model addresses the following question: How do changes in the number of HER2 and EGFR receptors during the cell-cycle affect the cell proliferation rate? In order to characterize the effects of HER2 over-expression on the cell cycle progression, we use a three-compartment cell cycle model with non-constant transition rates. Our new hypothesis is that the transition rates depend on the number of the cell surface HER2 receptors and their signaling properties. The model relates the different phases of the cell cycle transition rates to the signaling properties of the EGFR-HER2 receptors (through their binding kinetics), and the population dynamics of cells in the corresponding cell-cycle phase.
Date received: May 1, 2008
Copyright © 2008 by the author(s). The author(s) of this document and the organizers of the conference have granted their consent to include this abstract in Atlas Conferences Inc. Document # cawd-46.