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Mathematical Modeling for The effects of HER2 Overexpression in Breast Cancer
by
Amina Eladdadi
Mathematical Sciences Department at Rensselaer Polytechnic Institute , TROY, NY
Coauthors: David Isaacson
Over-expression of the HER2 receptor due to the neu gene amplification contributes to the development of human breast cancers. We present a mathematical model to study the effects of HER2 over-expression on cell proliferation. This mathematical model comprises kinetic equations describing the cell surface binding of EGF growth factor to EGFR and HER2 receptors, coupled to a model for the dependence of cell proliferation rate on growth factor receptors binding. The cell proliferation models enable us to simulate the proliferative behavior of the HER2-overexpressing cells with various HER2 and EGFR expression levels at various ligand concentrations. This model predicts a growth advantage associated with excess in cell surface HER2 receptors.
Date received: September 14, 2008
Copyright © 2008 by the author(s). The author(s) of this document and the organizers of the conference have granted their consent to include this abstract in Atlas Conferences Inc. Document # caww-30.