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Society for Mathematical Biology Conference
July 30 - August 2, 2008
Centre for Mathematical Medicine, Fields Institute
Toronto, Canada

Organizers
Organizing Committee: S.Sivaloganathan-Chair(Waterloo), M.Kohandel (Waterloo), I.Pressman(Carleton), F.Skinner(Toronto Western Research Inst.), H. Zhu(York)

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Quantifying the advantages of early intervention on Lupus Nephritis flares
by
Paula Budu-Grajdeanu
Mathematical Biosciences Institute
Coauthors: Richard C. Schugart, Avner Friedman, Daniel J. Birmingham and Brad H. Rovin

Although the prognosis for lupus nephritis (LN) has dramatically improved with aggressive immunosuppressive therapies, the current approach to treatment remains inadequate. It is likely that combinations of biomarkers will be needed to accurately describe the evolution of LN flare and to forecast impending LN flares. To demonstrate the utility and feasibility of lupus biomarker development, we develop a mathematical model of lupus renal flare that quantifies reduction in immunosuppressive medication as a function of how early flare is detected. The results suggest that early initiation of treatment is advantageous. Further refinement of the model, incorporating clinical and biomarker data, will benefit patients by allowing physicians to individualize immunosuppressive therapies.

Date received: May 15, 2008

Copyright © 2008 by the author(s). The author(s) of this document and the organizers of the conference have granted their consent to include this abstract in Atlas Conferences Inc. Document # caxj-23.