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Host: International Conference Centre Il Ciocco
Homepage: http://www.esf.org/euresco/01/mc01168a.htm
Email: euresco@esf.org
Organizers: C. Baron (München)
Description:
Type IV secretion machineries mediate direct
cell-to-cell transfer or secretion of virulence
factors from Gram-negative pathogens to modulate
their hosts defense response.
This strategy is used by many important human and
animal pathogens, such as Helicobacter pylori,
Bordetella pertussis, Brucells suis, Legionella
pneumophila and Rickettsia prowazekii. Type IV secretion
machineries also mediate the spread of plasmids carrying
antibiotic resistance genes between Gram-negative
pathogens, e. g. Pseudomonas aeruginosa, and genetic
transformation of plants by Agrobacterium tumefaciens.
Talks and posters will present recent work on basic aspects, such as DNA processing, transfer of virulence factors, host response and ecological implications.
The exchange between scientists from different backgrounds (medical, biochemical and ecological) in roundtable discussions will help to advance the understanding of basic (model of the mechanism of type IV secretion) as well as applied aspects (inhibitors of type IV secretion-mediated transfer processes).
Date received: April 29, 2001
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