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Email: ateliers@tolbiac.inserm.fr
Organizers: Thierry Galli (Inserm/Institut Jacques Monod, Paris), David Holcman (Ecole Normale Supérieure, Paris)
Deadline for abstracts: January 11, 2008
Description:
The goal of this workshop is to introduce various concepts of biophysical modeling to analyze cellular biology processes. In the past 10 years, new technologies revealed events occurring in cell at the scale of few micrometers and few milliseconds and was applied to correlate in space and time, various parameters at the cellular level or inside the living tissue. It became possible to observe and to quantify processes such as diffusion of molecules and vesicles, transport, interaction and resident time in macromolecular assemblies. Modeling is a fundamental tool to describe and quantify these processes. We will explain and detail how modeling is used in cellular biology. In particular, we will discuss the connection between biophysical models its mathematical analysis. We will underlie how a modeling approach is relevant to study event at a molecular level and focus on particular questions such as: What is the meaning of a chemical reaction at a molecular level? How chemical reactions can be extracted when few molecules are involved. Other examples will be given such as: How to extract the activation time constant and the time a receptor spends inside microdomain, using FRAP or FCS experiments or how to model cellular and viral intracellulartrafficking?
This workshop is open to a large public of students, engineers, researchers in the area of biophysics, cell biology, physics, chemistry and mathematics.
Lectures will be given in English.
Programme
- Basic concept of mathematical modeling in this area,
- Biophysical modeling of molecule, vesicle and virus trajectories,
- Cytoplasmic and surface trafficking, which may occur by diffusion but also
by active transport,
- Microdomain formation greatly influences the movement of proteins, molecules
and ions. As an example, we shall study synaptic microdomain where
receptor trafficking plays a fundamental role in the maintenance and the
plasticity of synapses,
- Neurite, dendrite and axonal growth,
- Cellular communication relies on exchange of chemical compounds from
one cell to another which is a fundamental step of morphogenetic gradient
construction.
Phase II
Technical workshop: November 2008 • Paris/Toul ouse
Programme
1. Biophysical modeling of molecular, vesicular and viral trajectories: theory,
simulations of trajectory reconstructions,
2. Microdomains in cellular biology: from synapses, neurites, dendrites and
axons: introduction to the modeling and simulation tools,
3. Morphogenetic gradients, from a single to several cells: modeling and experiments,
4. Signal transduction: modeling signaling pathways.
Selection
18 participants will be selected on the basis of individual project involving
biophysical modeling and mathematical analysis.
With :
Robert Austin (Princeton, USA), Maïté Coppey-Moisan (Paris, France), Nicolas Destainville (Toulouse, France), Michael Elbaum (Rehovot, Israel), Bart Ermentrout (Pittsburgh, USA), Thierry Galli (Paris, France), Ari Helenius (Zurich, Switzerland), David Holcman (Paris, France), Pierre-François Lenne (Marseille, France), Samir Mitragotri (Santa Barbara, USA), Gary Nolan (Stanford, USA), Stanislav Schvartsman (Princeton, USA), Antoine Triller (Paris, France)
Mail Address:
33(0)1.44.23.62.04 33(0)1.44.23.62.93 ateliers@tolbiac.inserm.fr
Submitted by: Cindy LINCY
Date received: November 07, 2007, revised November 14, 2007
© 2008 Atlas Conferences Inc.